IIB-INTECH - Jueves 23 de Marzo de 2017
Instituto de Investigaciones Biotecnologicas
Instituto Tecnológico de Chascomús

"Dr. Rodolfo A. Ugalde"

Universidad Nacional de San Martín
Consejo Nacional de Investigaciones Científicas y Técnicas
IIB-INTECH UNSAM-CONICET

 Covers

The Trypanosoma cruzi surface, a nanoscale patchwork quilt.

Mucci, J., Lantos, A.B., Buscaglia, C.A., Leguizamón, M.S. and Campetella, O.

  1. Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico de Chascomús (IIB-INTECH), Universidad Nacional de San Martín (UNSAM) - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), B1650HMP San Martín, Buenos Aires, Argentina.
  2. Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico de Chascomús (IIB-INTECH), Universidad Nacional de San Martín (UNSAM) - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), B1650HMP San Martín, Buenos Aires, Argentina. Electronic address: oscar@unsam.edu.ar.

Abstract

The Trypanosoma cruzi trypomastigote membrane provides a major protective role against mammalian host-derived defense mechanisms while allowing the parasite to interact with different cell types and trigger pathogenesis. This surface has been historically appreciated as a rather unstructured 'coat', mainly consisting of a continuous layer of glycolipids and heavily O-glycosylated mucins, occasionally intercalated with different developmentally regulated molecules displaying adhesive and/or enzymatic properties. Recent findings, however, indicate that the trypomastigote membrane is made up of multiple, densely packed and discrete 10-150nm lipid-driven domains bearing different protein composition; hence resembling a highly organized 'patchwork quilt' design. Here, we discuss different aspects underlying the biogenesis, assembly, and dynamics of this cutting-edge fashion outfit, as well as its functional implications.


Volume 33 , Issue 2 , 102 - 112 (2017)
IIB-INTECH-UNSAM-CONICET
Sede San Martín:
UNSAM - Campus Miguelete IIB - Instituto de Investigaciones Biotecnológicas, Av. 25 de Mayo y Francia CP(1650)
San Martín, Prov. de Buenos Aires, Argentina.
Tel. (5411)4006-1500 Fax: (5411)4006-1559 Email: iib-intech@unsam.edu.ar
Sede Chascomús:
Av. Intendente Marino Km 8,200 CC 164 (7130) Chascomús, Prov. de Buenos Aires, Argentina.
Tel. (542241)430323, 424045 Fax: (542241)424048
Email: intech@intech.gov.ar Contacto: Maria Inés Pietrantuono mpietran@intech.gov.ar